Contact Information

Food Safety and Toxicology Building
1129 Farm Lane, Room 212
Michigan State University
East Lansing, MI 48824

517-353-8627

Email: harkemaj@msu.edu

Education

  • BS, Calvin College, 1975
  • MS, Michigan State University, 1977
  • DVM, Michigan State University, 1980
  • Postdoctoral Fellowship, Lovelace Respiratory Research Institute, 1980-82
  • Residency in Veterinary Anatomic Pathology, University of California, Davis, 1982-85
  • PhD, University of California, 1985
  • Diplomate, American College of Veterinary Pathologists, 1988

Research Program

  • To understand the pathologic basis of health effects caused by environmental and occupational air pollutants
  • Using laboratory animal models of respiratory, cardiovascular, autoimmune and metabolic diseases to explore how chronic diseases effect susceptibility to toxicity caused by inhaled toxicants (ozone, particulate matter and silica dust)
  • With the overall goal to experimentally elucidate cellular, molecular or biochemical targets for interventions to prevent (or treat) adverse effects caused by air pollution

Current Investigation

  • Role of group 2 innate lymphoid cells (ILC2s) in air pollutant-induced, allergen-independent asthma and rhinitis
  • Mechanisms of dietary lipid prevention/treatment for silica-induced autoimmunity
  • Airway and systemic inflammatory/immune responses to short-and long-term exposures to ambient air pollutants individually or as mixtures

Funding Sources

  • National Institutes of Health/National Institute of Environmental Health Sciences
  • Albert C. and Lois E. Dehn Endowment for Veterinary Medicine
  • Private industries and foundations

Teaching Interests

  • General pathology
  • Comparative pathology
  • Integrated toxicology
  • Respiratory pathobiology
  • Inhalation toxicology

Service

  • Standing Member, US EPA Clean Air Science Advisory Committee
  • Past Chair, Environmental, Occupational and Population Health Assembly of the American Thoracic Society
  • Past Member, Executive Council of the Society of Toxicologic Pathology

Board Certification

  • Diplomat of the American College of Veterinary Pathologists
PubMed Research

CVM Articles by Jack Harkema

MSU Today: Omega-3 fatty acid stops lupus trigger, but how? - June 01, 2017