The liver synthesizes numerous coagulation factors, making altered hemostasis a significant concern in patients with end-stage liver disease. Our laboratory approaches this connection early in the pathogenesis of liver disease. The team’s long-term goal is to understand the mechanisms whereby the coagulation cascade contributes to the pathogenesis of liver disease.
Researchers and students in the laboratory explore intersecting aspects of coagulation biology, including regulation of tissue factor procoagulant activity, coagulation protease signaling, the dynamic regulation of fibrin clot formation, and acute and chronic liver disease. Current research projects investigate mechanisms whereby elements of the coagulation cascade contribute to obesity-related diseases, including non-alcoholic fatty liver disease (NAFLD) and diabetes, chronic biliary fibrosis, and acetaminophen-induced liver injury. We have a longstanding interest in mechanisms whereby environmental exposures promote liver disease, and recent studies in the laboratory have identified a novel connection between environmental chemical exposure and biliary fibrosis triggered by autoimmunity.