June 14, 2021 8:26 AM

Beginning Monday, June 14, 2021, the MSU Veterinary Medical Center will allow clients into the building with patients. Find details here.

Any patient presented to the MSU Small Animal Emergency Service will undergo an initial medical evaluation to determine if urgent care is needed, and whether hospitalization is warranted. The MSU Small Animal Emergency Service will only hospitalize patients that our clinicians consider to be unstable or to have life-threatening conditions.

Contact Information

Email: janani@msu.edu

Phone: 517-353-5491

Veterinary Medical Center - South Building (Wings F - G)
784 Wilson RD, Room G304
East Lansing, MI 48824

Webpage: jravilab.github.io | CV

GitHub: jananiravi | jravilab

Twitter: janani137 | jravilab

Education

  • PhD in Genetics, Bioinformatics and Computational Biology, Virginia Tech, Blacksburg, VA, 2011
  • BTech in Biotechnology, Anna University, Chennai, India, 2006

Research

Dr. Ravi and her team develop computational approaches to study the molecular basis of pathogenesis and intervention of infectious diseases.

The research involves developing computational approaches that can leverage large-scale genomic data to gain actionable insights into infectious disease biology. Specifically, with a focus on three key areas:

i) unraveling molecular mechanisms common between non-infectious and infectious diseases, to guide targeted drug repurposing,

ii) identifying genomic signatures, functions, and mechanisms relevant to host-pathogen interactions, to enable understanding and guide diagnosis, and

iii) developing tools and resources for seamlessly relating sequence, structure, and function of genes/proteins in poorly characterized pathogens.

Keywords

Computational biology/bioinformatics | molecular evolution and phylogeny | comparative pathogenomics | drug repurposing | genomics/transcriptomics | infectious diseases | R for biological data science

Current Research Projects

Recent Publications

  • Chen SZ#, Sosinski LM#, Johnston JB, Ravi J. MolEvolvR: A web-app for characterizing proteins using molecular evolution and phylogeny. [submitted to Nucleic Acids Research] [Webapp]
  • Samart K#, Tuyishime P#, Krishnan A, Ravi J. Reconciling multiple connectivity scores for drug repurposing. 2020 [arXiv] [Live doc] [GitHub] [under revision at Briefings in Bioinformatics]
  • Ravi J, Anantharaman V, Chen SZ, Datta, P, Aravind L, Gennaro ML. Phage-shock-protein (Psp) Envelope Stress Response: Evolutionary History & Discovery of Novel Players. 2020. [bioRxiv] [Webapp] [in preparation for Molecular Biology and Evolution]
  • Ravi J#ℂ, Fioravanti A#ℂ. S-layers: the proteinaceous multifunctional armours of Gram-positive pathogens. Frontiers in Microbiology, Special Issue on Cell Surface Proteins of Gram-positive Pathogenic Bacteria. 2021.
  • Hadi SA, Kolte IV, Brenner EP, Cunha EAT, Simonsen V, Ferrazoli L, Villela DAM, Santos RS, Ravi J, Sreevatsan S, Basta PC. Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population. Scientific Reports. 2021 Jan 13;11(1):1224. PMID: 33441660.
  • Lensmire JM, Dodson JP, Hsueh BY, Wischer MR, Delekta PC, Shook JC, Ottosen EN, Kies PJ, Ravi J, Hammer ND. The Staphylococcus aureus cystine transporters, TcyABC and TcyP, facilitate nutrient sulfur acquisition during infection. Infection and Immunity. 2019 Dec; epub. PMID: 31843961.

#Co-primary authors; Co-corresponding authors.

Honors and Awards

  • 2021 – 2023 Harvey J Fiege Endowed Research Fund, College of Vet Med, MSU (PI)
  • 2021 – 2022 Spectrum Health and MSU Alliance (PI: Jeremy Prokop, Nicholas Hartog)
  • 2021 – 2022 NSF-funded BEACON (PI)
  • 2020 – 2021 NIH R01 Sub-award for summer support. (PI: Neal Hammer)
  • 2019 – 2021 Harvey J Fiege Endowed Research Fund, College of Vet Med, MSU (PI)
  • 2019 – 2020 Diversity Research Network, Launch Awards Program, MSU (PI)
  • 2019 – 2020 All-University Excellence in Diversity Award, Michigan State University (for R-Ladies East Lansing)
  • 2019 – 2020 MSU Data Science Learning Community funded by the MSU Academic Advancement Network
  • 2019 – Now Sponsorship for Women+ Data Science East Lansing @MSU symposia
  • 2018 – Now Sponsorships for 25+ R-Ladies East Lansing meetups

Education and Outreach

    • 2019 – Co-founder and Co-organizer, MSU Data Science Learning Community; Co-founder and Co-organizer, Women+ Data Science with MSU, UMich
    • 2019 – Member, Data Carpentry | Genomics and Open Science Education teams
    • 2018 – Member, R-Ladies Global; Women in Data Science; rOpenSci
    • 2018 – Founder and Co-organizer, R­-Ladies East Lansing