CHOP vs. LOPP chemotherapy as a first line treatment for naïve peripheral T cell lymphoma in dogs

Species: Dog

Area of Study: Medical Oncology

Purpose of Study: The purpose of this study is to provide a direct comparison between the outcomes for dogs with TCL treated with CHOP or LOPP chemotherapy. The findings of this study could help veterinarians understand if one protocol is truly superior to the other for dogs with TCL. In this study, your dog will be randomly selected to receive either CHOP or LOPP chemotherapy. At each visit, their lymph node size, blood work, and overall wellbeing will be assessed. Both protocols involve treatments every 7-14 days and take 4-6 months to complete. Following protocol completion, your pet will return once monthly to assess remission status.


Your dog may qualify if:

  • Confirmed T cell lymphoma diagnosis via cytology or histopathology.
    • No indolent forms of lymphoma, such as T zone lymphoma.
  • No prior anti-cancer treatment, including steroids, within 7 days.
  • No major lab work abnormalities that prevent chemotherapy administration.
  • No evidence of dilated cardiomyopathy, ventricular arrhythmia, or liver failure.

Client Benefits

This is a partially funded trial: dogs will receive the first dose of doxorubicin or lomustine free of cost. Examination, diagnostic, and administration fees will the pet owner’s responsibility. Pet owners are financially responsible for all treatments and diagnostics that are unrelated to the study.

Client Responsibilities

  • To administer prednisone, chemotherapy, or supplemental medications as prescribed by the attending veterinarian.
  • To comply with the visit schedule outlined by study investigators
  • To report any abnormal behavior or signs of illness to study investigators.
  • To contact study investigators if your dog is evaluated by any other veterinarians during the course of the study.
  • To inform study investigators of any non-study related veterinary treatments recommended for your dog during the course of the study.

Contact Information

Please feel free to contact our Medical Oncology Team at (517) 353-5420 or to refer a patient or for any additional information. Referring veterinarian and client calls are welcome.