Featured Publications
Mackey E, Moeser AJ. Sex Differences in Mast Cell-Associated Disorders: A Life Span Perspective. Cold Spring Harb Perspect Biol. 2022 Jul 11:a039172. doi: 10.1101/cshperspect.a039172. Epub ahead of print. PMID: 35817512.
Moeser AJ, Roney A, Fardisi M, Thelen K. Invited review: Biological sex: an understudied factor driving disease susceptibility in pigs. J Anim Sci. 2022 Jun 1;100(6):skac146. doi: 10.1093/jas/skac146. PMID: 35708590; PMCID: PMC9202566.
Piliponsky AM, Sharma K, Quach P, Brokaw A, Nguyen S, Orvis A, Saha SS, Samanas NB, Seepersaud R, Tang YP, Mackey E, Bhise G, Gendrin C, Furuta A, Seo AJ, Guga E, Miralda I, Coleman MM, Sweeney EL, Bäuml CA, Imhof D, Snyder JM, Moeser AJ, Rajagopal L. Mast cell derived factor XIIIA contributes to sexual dimorphic defense against group B Streptococcal infections. J Clin Invest. 2022 Aug 25:e157999. doi: 10.1172/JCI157999. Epub ahead of print. PMID: 36006736.
Duque-Wilckens N, Teis R, Sarno E, Stoelting F, Khalid S, Dairi Z, Douma A, Maradiaga N, Hench S, Dharshika CD, Thelen KM, Gulbransen B, Robison AJ, Moeser AJ. Early life Adversity Drives Sex-Specific Anhedonia and Meningeal Immune Gene Expression Through Mast Cell Activation. Brain Behav Immun. 2022 Mar 23:S0889-1591(22)00077-0. doi: 10.1016/j.bbi.2022.03.009. Epub ahead of print. PMID: 35339629.
Li, Y., Thelen, K.M., Matos Fernández, K., Nelli, R., Fardisi, M., Rajput, M., Trottier, N.L., Contreras, G.A. and Moeser, A.J., 2022. Developmental Alterations of Intestinal SGLT1 and GLUT2 Induced by Early Weaning Coincides with Persistent Low-Grade Metabolic Inflammation in Female Pigs. American Journal of Physiology-Gastrointestinal and Liver Physiology. https://doi.org/10.1152/ajpgi.00207.2021
Mackey, E., Thelen, K.M., Bali, V., Fardisi, M., Trowbridge, M., Jordan, C.L. and Moeser, A.J. Perinatal androgens organize sex differences in mast cells and attenuate anaphylaxis severity into adulthood. Proceedings of the National Academy of Sciences, 117(38), pp.23751-23761, 2020. PMID: 32917815, DOI: https://doi.org/10.1073/pnas.1915075117
D'Costa S, Ayyadurai S, Gibson AJ, Mackey E, Rajput M, Sommerville LJ, Wilson N, Li Y, Kubat E, Kumar A, Subramanian H, Bhargava A, Moeser AJ. Mast Cell CRF2 Suppresses Mast Cell Degranulation and Limits the Severity of Anaphylaxis and Stress-Induced Intestinal Permeability. J Allergy Clin Immunol. 2018 10.1016/j.jaci.2018.08.053. PMID: 30439403
Ayyadurai S, Gibson AJ, D'Costa S, Overman EL, Sommerville LJ, Poopal AC, Mackey E, Li Y, Moeser AJ. Frontline Science: Corticotropin-releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress-induced pathophysiology. AJ. J Leukoc Biol 102(6):1299-1312. PMID: 28684600 *selected for editorial focus
Pohl CS, Medland JE, Mackey E, Edwards LL, Bagley KD, Dewilde MP, Williams KJ, Moeser AJ. Early weaning stress induces chronic functional diarrhea, intestinal barrier defects, and increased mast cell activity in a porcine model of early life adversity. Neurogastroenterology and Motility. 2017. PMID: 28573751 *selected for editorial focus
Mackey EM, Ayyadurai S, Pohl CS, D’Costa S, Li Y, Moeser AJ. Sexual dimorphism in the mast cell transcriptome and the pathophysiological responses to immunological and psychological stress. Biology of Sex Differences 7:60, 2016. PMID: 27895892.
Choi H, Bowen SE, Mio Y, Chan CY, Mioa EA, Abrink M, Moeser AJ, and Abraham SN. Loss of Bladder Epithelium Induced by Cytolytic Mast Cell Granules. Immunity 45:1258-1269, 2016. PMID: 27939674.