The Agnew Laboratory focuses on comparative reproductive pathology, zoo and wildlife pathology, conservation biology, infectious diseases in the bovine reproductive tract, and international development and livestock diseases, particularly in Ghana.
Dalen Agnew, DVM, PhD, DACVP, is researching reproductive lesions of captive suids, ovarian carcinoma in jaguars, reproductive lesions of polar bears, reproductive and aporcine gland disease of African painted dogs, and digital tools to enhance pathology collaborations with colleagues in Africa.
Current Research
Lab News
Bridging the Lab and the Zoo: How MSU Veterinary Scholars Are Safeguarding Endangered Species
At the 2026 Veterinary Scholars Symposium, Abby Boss, Grace Sherlitz, and Yuri Kim represented the Agnew Lab. Above, Yuri Kim presents her poster, "Characterizing age-related changes in the testes and epididymides of zoo-managed African painted dogs." Above right, Abby Boss presents her poster, "Retrospective analysis of the reproductive lesions of captive callitrichidae and potential risk factors."
At the 2026 Society for Theriogenology Conference, Bonnie Howard presented her research, "Epididymal adenomatous hyperplasia: is there a relationship with testicular disease?"
Recent Publications
Fayette, M. A., Moresco, A., Bassiouny, E., Agnew, D. W., & Petroff, B. (2026). Validation of Immunoassays for Total Thyroxine and Free Thyroxine and Age and Sex-Related Variation in Thyroid Hormone Serum Concentrations in Orangutans (Pongo sp.). Journal of medical primatology, 55(3), e70073. https://doi.org/10.1111/jmp.70...
McAloose, D., Bartlett, S. L., Wise, A. G., Mack, Z. E., De Koch, M. D., Kraberger, S., Varsani, A., Spokony, R., Nightingale, B. R., Stout, C. M., Doherty, D., Craft, D., Maes, R., Agnew, D., & Seimon, T. A. (2026). ORAL AND GASTRIC PLAQUES, PAPILLOMAS, SQUAMOUS CELL CARCINOMAS AND PAPILLOMAVIRUSES IN SLENDER-HORNED GAZELLES (GAZELLA LEPTOCEROS ). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 57(2), 393–405. https://doi.org/10.1638/2024-0...
Rooney, T. A., Lehner, A., Zyskowski, J., Thompson, K. A., Eustace, R., Kozlowski, C. P., Clawitter, H., McDonald, M. M., Franklin, A. D., Powell, D., Buchweitz, J., & Agnew, D. (2025). DEVELOPMENT AND VALIDATION OF DESLORELIN ACETATE ASSAY AND A PILOT STUDY ON THE PHARMACOKINETICS OF DESLORELIN ACETATE IMPLANTS AND FECAL HORMONE MONITORING IN THE DOMESTIC GOAT (CAPRA HIRCUS). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 56(3), 548–557. https://doi.org/10.1638/2024-0...
Oliveira Filho, H. S., Duarte, J. L. C., Paranhos, G. F., Silva, J. P. G. D., Neto, P. M. D. N., Lins, B. B., M Dos Santos, W., Júnior, L de Oliveira, R., Santos, R. L., Pavarini, S. P., Tsoi, M. F., Agnew, D., & Leal de Araújo, J. (2026). Clinicopathological findings of sustentacular cell tumors in 13 singing tournament passerine birds. Veterinary pathology, 3009858261477048. Advance online publication. https://doi.org/10.1177/030098...
Zayas, S., Buchweitz, J., Beierschmitt, A., Palmour, R. M., Agnew, D., Pithua, P. O., & Bolfa, P. (2026). Hemosiderosis in St. Kitts African green monkeys (Chlorocebus sabaeus). Veterinary pathology, 63(2), 345–356. https://doi.org/10.1177/030098...
Bi-Macroaggregated Albumin Inhibited Mouse Melanoma Growth by Regulating Cell Cycle Checkpoint Markers Without Promoting Living Cell Repopulation. J Nucl Med. 2025 Apr 3 https://jnm.snmjournals.org/content/early/2025/04/03/jnumed.124.269190.long
Certifying "day one ready" pathologists: Are we accomplishing our goals? Vet Pathol. 2025 Mar https://journals.sagepub.com/doi/10.1177/03009858241302843?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Clinical Scaleup of Humanized AnnA1 Antibody Yielded Unexpected High Reticuloendothelial (RES) Uptake in Mice. Antibodies (Basel). 2025 Feb 6 https://www.mdpi.com/2073-4468/14/1/14
Endocrine Diagnostics: Principles and Applications. Vet Clin North Am Exot Anim Pract. 2025 Jan https://www.sciencedirect.com/science/article/pii/S1094919424000367?via%3Dihub
Atypical granulation in neutrophils of a domestic shorthair cat. Vet Clin Pathol. 2024 Jun https://onlinelibrary.wiley.com/doi/10.1111/vcp.13356
Recurrent and convolutional neural networks for sequential multispectral optoacoustic tomography (MSOT) imaging. J Biophotonics. 2023 Nov https://onlinelibrary.wiley.com/doi/10.1002/jbio.202300142
Pathology of Perinatal Disorders. Vet Clin North Am Small Anim Pract. 2023 Sep https://www.sciencedirect.com/science/article/pii/S0195561623000700?via%3Dihub
Endometrial hyperplasia with loss of APC in a novel population of Lyz2-expressing mouse endometrial epithelial cells. Carcinogenesis. 2023 May 15 https://academic.oup.com/carcin/article/44/1/54/6957331
New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape. Biol Open. 2023 Mar 15 https://journals.biologists.com/bio/article/12/3/bio059647/297287/New-K50R-mutant-mouse-models-reveal-impaired
Piscichuvirus-Associated Severe Meningoencephalomyelitis in Aquatic Turtles, United States, 2009-2021. Emerg Infect Dis. 2023 Feb https://wwwnc.cdc.gov/eid/article/30/2/23-1142_article
What is your diagnosis? Abdominal mass from a dog. Vet Clin Pathol. 2022 Dec https://onlinelibrary.wiley.com/doi/10.1111/vcp.13082
Super-resolution and segmentation deep learning for breast cancer histopathology image analysis. Biomed Opt Express. 2022 Dec 5 https://pmc.ncbi.nlm.nih.gov/articles/PMC9841988/
Distribution of canine distemper virus and nectin-4 in raccoon (Procyon lotor) skin. Vet Pathol. 2022 Sep https://journals.sagepub.com/doi/10.1177/03009858221102598?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Reproductive one health in primates. Am J Primatol. 2022 May https://onlinelibrary.wiley.com/doi/10.1002/ajp.23325