Some ocular help from man’s best friend
June 2015 (DDNews: Pharma, Biotech & Life Science) -- Dr. Komáromy and University of Pennsylvania collaborator Dr. Gustavo Aguirre presented new preclinical data that evaluates the efficacy of a gene therapy treatment for achromatopsia, which affects humans as well as dogs.
Team from MSU and Penn Develops Novel Gene Therapy
May 7, 2015 (Research @ MSU) -- New gene therapy treatment demonstrates a functional rescue of cone cells in nearly 100 percent of eyes treated. Research was co-led by Dr. Komáromy and Dr. Gustavo Aguirre, professor of medical genetics and ophthalmology at the University of Pennsylvania
Andras Komaromy, PhD, wins Shaffer Award for research of gene therapy to control IOP
Feb 05, 2015 (Ophthalmology Times) -- Dr. Komáromy receives award for his research on the potential of gene therapy to provide lasting control of intraocular pressure in glaucoma patients with known genetic defects. Includes audio interview.
Jan 21, 2015 (MSU Today) -- Voices and Viewpoints: Faculty Voices feature on Dr. Komáromy’s work on inherited blinding diseases affecting both animals and humans, as well as his clinical work.
Dog blindness may lead to insights into human blindness -- CNN.com
Jan 2, 2015 (CNN) -- In a decade-long journey across three continents, Komáromy and long-term collaborators identified a new form of progressive retinal atrophy in Swedish Vallhund dogs and have now found a gene defect responsible for the disease. The findings also provide important insight into blinding diseases in humans.
Komáromy selected to receive a 2015 ARVO Foundation/Pfizer Ophthalmics Carl Camras Translational Research Award
May 8, 2014 (Association for Research in Vision and Ophthalmology) -- The award recognizes a researcher who has exhibited excellence in research and fundamental scientific discoveries, concepts, and novel technologies. Awardees are recognized for a discovery or observation that has led to, or has the promise of leading to, clinical application.
Dr. Komáromy receives 2013 Shaffer Grant for Innovative Glaucoma Research
March 28, 2013 (Glaucoma Research Foundation) -- Dr. Komáromy receives grant for project "Gene Therapy in a Spontaneous Canine Model of Primary Open-Angle Glaucoma."
"One-two punch could be key in treating blindness"
April 9, 2013 (MSU Today) -- The Komáromy Lab proposes a new concept of retinal therapy—a combination therapy that maximizes therapeutic success.
Sudden acquired retinal degeneration syndrome (SARDS) - a review and proposed strategies toward a better understanding of pathogenesis, early diagnosis, and therapy. Komáromy AM, Abrams KL, Heckenlively JR, Lundy SK, Maggs DJ, Leeth CM, MohanKumar PS, Petersen-Jones SM, Serreze DV, van der Woerdt A. Vet Ophthalmol. 2015 Jun 20. doi: 10.1111/vop.12291.
Dog models for blinding inherited retinal dystrophies. Petersen-Jones SM, Komáromy AM. Hum Gene Ther Clin Dev. 2015 Mar;26(1):15-26. doi: 10.1089/humc.2014.155. Epub 2015 Feb 11.
Dog Models for Blinding Inherited Retinal Degenerations.Petersen-Jones S, Komaromy AM. Hum Gene Ther Clin Dev. 2014 Dec 30.
Increased expression of MERTK is associated with a unique form of canine retinopathy. Ahonen SJ, Arumilli M, Seppälä E, Hakosalo O, Kaukonen MK, Komáromy AM, Lohi H. PLoS One. 2014 Dec 17;9(12):e114552. doi: 10.1371/journal.pone.0114552. eCollection 2014.
A Novel Missense Mutation in ADAMTS10 in Norwegian Elkhound Primary Glaucoma. Ahonen SJ, Kaukonen M, Nussdorfer FD, Harman CD, Komáromy AM, Lohi H. PLoS One. 2014 Nov 5;9(11):e111941. doi: 10.1371/journal.pone.0111941. Free PMC Article.
A novel form of progressive retinal atrophy in Swedish vallhund dogs. Cooper AE, Ahonen S, Rowlan JS, Duncan A, Seppälä EH, Vanhapelto P, Lohi H, Komáromy AM. PLoS One. 2014 Sep 8;9(9):e106610. doi: 10.1371/journal.pone.0106610. Free PMC Article.
A cyclic nucleotide-gated channel mutation associated with canine daylight blindness provides insight into a role for the S2 segment tri-Asp motif in channel biogenesis. Tanaka N, Delemotte L, Klein ML, Komáromy AM, Tanaka JC. PLoS One. 2014 Feb 21;9(2):e88768. doi: 10.1371/journal.pone.0088768. eCollection 2014. Free PMC Article
Transient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia. Komáromy AM, Rowlan JS, Corr AT, Reinstein SL, Boye SL, Cooper AE, Gonzalez A, Levy B, Wen R, Hauswirth WW, Beltran WA, Aguirre GD. Mol Ther. 2013 Jun;21(6):1131-41. doi: 10.1038/mt.2013.50. Free PMC Article.
Tapetal dysplasia in a Swedish Vallhund dog. Scott EM, Teixeira LB, Dubielzig RR, Komáromy AM. Vet Ophthalmol. 2013 Jul;16 Suppl 1:145-50. doi: 10.1111/vop.12031.
Biomechanical Properties and Correlation with Collagen Solubility Profile in the Posterior Sclera of Canine Eyes with an ADAMTS10 Mutation. Palko JR, Iwabe S, Pan X, Agarwal G, Komáromy AM, Liu J. Invest Ophthalmol Vis Sci. 2013 Mar 21. doi:pii: iovs.12-10621v1. 10.1167/iovs.12-10621
Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement. Cideciyan AV, Jacobson SG, Beltran WA, Sumaroka A, Swider M, Iwabe S, Roman AJ, Olivares MB, Schwartz SB, Komáromy AM, Hauswirth WW, Aguirre GD. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E517-25. doi: 10.1073/pnas.1218933110. Epub 2013 Jan 22.
Investigating the inheritance of prolapsed nictitating membrane glands in a large canine pedigree. Edelmann ML, Miyadera K, Iwabe S, Komáromy AM. Vet Ophthalmol. 2012 Dec 13. doi: 10.1111/vop.12015
Tapetal dysplasia in a Swedish Vallhund dog. Scott EM, Teixeira LB, Dubielzig RR, Komáromy AM. Vet Ophthalmol. 2013 Feb 13. doi: 10.1111/vop.12031. [Epub ahead of print]
Gene therapy rescues cone function in congenital achromatopsia. Komáromy AM, Alexander JJ, Rowlan JS, Garcia MM, Chiodo VA, Kaya A, Tanaka JC, Acland GM, Hauswirth WW, Aguirre GD. Hum Mol Genet. 2010 Jul 1;19(13):2581-93. doi: 10.1093/hmg/ddq136. Epub 2010 Apr 8. Erratum in: Hum Mol Genet. 2011 Dec 15;20(24):5024.