Monica Jacobs

Degree Seeking

PhD

Year Joined CMIB

2019

Mentor(s)

Dana Spance

Research Interests

My primary research focuses on Type 1 Diabetes and how to alleviate the microvascular complications associated with this disease. I study a molecule, C-peptide, that is released in equimolar amounts to insulin from the pancreatic beta-cell, in hopes to use this as a therapy for diabetic complications attributed to decreased blood flow. Prior research has shown that a combination of zinc, C-peptide, and human serum albumin (HSA) are required to transport C-peptide through the blood stream to elicit its therapeutic effects. I investigate how this C-peptide complex is transported in the bloodstream under diabetic conditions to understand how this molecule can be used in vivo as a therapy for T1D.