June 14, 2021 8:26 AM

Beginning Monday, June 14, 2021, the MSU Veterinary Medical Center will allow clients into the building with patients. Find details here.

Any patient presented to the MSU Small Animal Emergency Service will undergo an initial medical evaluation to determine if urgent care is needed, and whether hospitalization is warranted. The MSU Small Animal Emergency Service will only hospitalize patients that our clinicians consider to be unstable or to have life-threatening conditions.

Contact Information

Food Safety and Toxicology Building
1129 Farm Lane, Room 212
Michigan State University
East Lansing, MI 48824

517-353-8627

Email: harkemaj@msu.edu

Education

  • BS, Calvin College, 1975
  • MS, Michigan State University, 1977
  • DVM, Michigan State University, 1980
  • Postdoctoral Fellowship, Lovelace Respiratory Research Institute, 1980-82
  • Residency in Veterinary Anatomic Pathology, University of California, Davis, 1982-85
  • PhD, University of California, 1985
  • Diplomate, American College of Veterinary Pathologists, 1988
  • Fellow, American Thoracic Society, 2018

Research Program

  • To understand the pathologic basis of health effects caused by environmental and occupational air pollutants
  • Using laboratory animal models of respiratory, cardiovascular, autoimmune and metabolic diseases to explore how chronic diseases effect susceptibility to toxicity caused by inhaled toxicants (ozone, particulate matter and silica dust)
  • With the overall goal to experimentally elucidate cellular, molecular or biochemical targets for interventions to prevent (or treat) adverse effects caused by air pollution

Current Investigation

  • Role of group 2 innate lymphoid cells (ILC2s) in air pollutant-induced, allergen-independent asthma and rhinitis
  • Mechanisms of dietary lipid prevention/treatment for silica-induced autoimmunity
  • Airway and systemic inflammatory/immune responses to short-and long-term exposures to ambient air pollutants individually or as mixtures

Funding Sources

  • National Institutes of Health/National Institute of Environmental Health Sciences
  • Albert C. and Lois E. Dehn Endowment for Veterinary Medicine
  • Private industries and foundations

Teaching Interests

  • General pathology
  • Comparative pathology
  • Integrated toxicology
  • Respiratory pathobiology
  • Inhalation toxicology

Service

  • Standing Member, US EPA Clean Air Science Advisory Committee
  • Past Chair, Environmental, Occupational and Population Health Assembly of the American Thoracic Society
  • Past Member, Executive Council of the Society of Toxicologic Pathology

Board Certification

  • Diplomat of the American College of Veterinary Pathologists
PubMed Research