Harkema

Food Safety and Toxicology Building
1129 Farm Lane, Room 212
Michigan State University
East Lansing, MI 48824

Phone: 517-353-8627

BS, Calvin College, 1975
MS, Michigan State University, 1977
DVM, Michigan State University, 1980
Postdoctoral Fellowship, Lovelace Respiratory Research Institute, 1980-82
Residency in Veterinary Anatomic Pathology, University of California, Davis, 1982-85
PhD, University of California, 1985
Diplomate, American College of Veterinary Pathologists, 1988
Fellow, American Thoracic Society, 2018

To understand the pathologic basis of health effects caused by environmental and occupational air pollutants
Using laboratory animal models of respiratory, cardiovascular, autoimmune and metabolic diseases to explore how chronic diseases effect susceptibility to toxicity caused by inhaled toxicants (ozone, particulate matter and silica dust)
With the overall goal to experimentally elucidate cellular, molecular or biochemical targets for interventions to prevent (or treat) adverse effects caused by air pollution
Genetic analysis of COVID-19 susceptibility and resistance determinants (e.g., pulmonary histopathology) in collaborative cross mice

Role of group 2 innate lymphoid cells (ILC2s) in air pollutant-induced, allergen-independent asthma and rhinitis
Mechanisms of dietary lipid prevention/treatment for silica-induced autoimmunity
Airway and systemic inflammatory/immune responses to short-and long-term exposures to ambient air pollutants individually or as mixtures

National Institutes of Health/National Institute of Environmental Health Sciences
Albert C. and Lois E. Dehn Endowment for Veterinary Medicine
Private industries and foundations

Past Member, US EPA Clean Air Science Advisory Committee
Past Chair, Environmental, Occupational and Population Health Assembly of the American Thoracic Society
Past Member, Executive Council of the Society of Toxicologic Pathology
Past Chair, American Thoracic Society Environmental Health Policy Committee