Gi Stress Bio Lab Team Photo

Dr. Adam Moeser, DVM, MS, PhD

Moeser

Associate Professor and Matilda R. Wilson Endowed Chair

Dr. Moeser joined the MSU College of Veterinary Medicine’s Department of Large Animal Clinical Sciences as associate professor and Matilda R. Wilson Endowed Chair in 2015.

He directs the Gastrointestinal Stress Biology Laboratory (GISBL). Dr. Moeser grew up in Massachusetts and earned a BS degree from the University of Massachusetts at Amherst in 2000, a master’s in Animal Nutrition in 2001, PhD in Physiology (under the direction of Anthony Blikslager) in 2006, and DVM in 2008 from the North Carolina State University. During his doctoral research at North Carolina State University, he studied mechanisms of intestinal injury under Dr. Anthony Blikslager, DVM PhD DACVS, Specifically his dissertation work focused on the role of intestinal epithelial ion transporters in the repair of intestinal barrier function following acute intestinal ischemia in porcine and murine models. Dr. Moeser was a recipient of NIH T32 post-doctoral fellowship based at The University of North Carolina at Chapel Hill (Center for Gastrointestinal Biology and Disease). He received an NIH K08 award from the NIDDK in 2008 where he trained under the mentorship of Dr. Soman Abraham (Duke University) in the area of Immunogy/mast cell biology.

Dr. Moeser has a passion for training the next generation of clinician and basic scientists and his trainees have received numerous accolades including prestigious NIH F30 and K01 awards, and have obtained competitive positions as post-docs, tenure-track faculty, industry scientists and directors and clinicians.

Dr. Moeser's publications

Emily Mackey, BS

Mackey

DVM/PhD student

Emily Mackey is a combined DVM/PhD student in the Comparative Biomedical Sciences Program at North Carolina State University. Emily’s PhD dissertation research is being conducted in the GISBL under the direction of Dr. Moeser. She received her bachelor’s in Pre-Veterinary and Animal Biosciences at the University of Delaware where she performed research involving nutritional immunology in dairy cattle.

Emily’s dissertation work involves elucidating the mechanisms of sexual dimorphism in mast cells and the influence of this on sex-biased diseases. Emily is a 2-time recipient of first place presenter awards at the NCSU and MSU CVM Annual Research Symposiums and was the recipient of the 2017 Elizabeth Young New Investigator Award presented at the 11th Annual Meeting of the Organization for the Study of Sex Differences, Montreal Quebec 2017 and was a travel award recipient in 2018. Emily was awarded an NIH F30 predoctoral fellowship in 2018.

Kyan Thelen, MS

Thelen

Laboratory manager and research associate

Kyan joined the GISBL in 2018 as a laboratory manager and research associate. She obtained her BS degree in Animal Science in 2015 and her MS degree in Comparative Medicine and Integrative Biology in 2017, both from Michigan State University. Her MS research, under Dr. Andres Contreras, focused on adipose tissue biology and modeling perivascular adipose tissue.

Nidia Maradiaga, MS

Maradiaga

PhD student

Nidia joined the GISBL lab in 2017 and is a pursuing a PhD through the Comparative Medicine and Integrative Biology program at the College of Veterinary Medicine at MSU. Nidia obtained her BS in Microbiology from the Universidad Nacional Autónoma de Honduras at Tegucigalpa, Honduras. She received a Master of Science degree in Veterinary Clinical Medicine from the University of Illinois at Urbana-Champaign under the direction of Drs. Jim Lowe and Brain Aldridge) which focused Impact of cross-fostering on the intestinal microbiome and mucosal immune gene expression in neonatal pigs. Nidia’s dissertation research in the GISBL is focused on epigenetic programming of mast cells in animal models of early life adversity and brain-gut axis disorders.

Natalia Duque Wilckens, DVM, PhD

Post-doctoral research associate

Dr. Natalia Duque-Wilckens joined the GISBL in September 2018 and will be co-mentored by Dr. AJ Robison (MSU Dept. of Physiology/Neuroscience). "I trained in veterinary sciences at the University of Chile. During this time I had the opportunity to work closely with different animal species in hospitals, farm, and laboratory settings, which raised a deep interest in understanding how affective states interact with other physiological variables to affect health and well-being. This led me to join the Animal Behavior Graduate program at UC Davis, where I used behavioral, pharmacological, and molecular approaches to identify neural circuits modulating social anxiety in California mice. I am really excited to join Dr. Moeser’s and Dr. Robinson’s labs to study how stress can affect the programming of the immune system during early development, and how that may result in long-lasting changes in gastrointestinal health, neurobiology, and behavior across species".

Neco Wilson, BS

Wilson

MS student

Neco Wilson Joined the GISBL in 2016 as a PhD student in the CMIB program at MSU. She obtained her BS degree from Michigan State University. Neco’s graduate research is centered on understanding how postnatal age influences GI mast cell activation in a porcine model of ELA. Neco is a MSU BEST (Broadening Experiences in Scientific Training) Trainee, a facilitator for the Summer Research Opportunities Program (SROP) and graduate student committee member and Assistant Editor for the Alliance for Graduate Education and the Professoriate (AGEP).

Lab Alumni

Saru Ayyadurai, PhD – Post-Doctoral Research Associate (2014-2017). Saru’s post-doctoral research focused on the role of the mast cell-CRF1 receptors as modulators of stress-induced mast cell activation and associated disease pathophysiology. He is currently employed as QC Scientist at Cytovance Biologics, Oklahoma City, OK

Beth Overman Cauley, PhD – Dr. Overman was the first graduate student in the GISBL and received her PhD in Physiology in 2011. Dr. Overman’s dissertation research focused on the role of intestinal CRF signaling in stress-induced intestinal barrier dysfunction in porcine models. Beth is currently an Assistant Professor at Campbell University in Buies Creek, NC.

Amelia Gibson, PhD MBA – Amelia received her PhD in 2012. Her dissertation research focused on the role of mast cell CRF receptor subtypes, CRF1 and CRF2, in modulating mast cell degranulation and stress-induced intestinal permeability. In 2012, Amelia joined KeraFast, Inc. (Boston, MA) as Director of Business Development.

Liz Lennon, DVM PhD DACVIM – Liz received her PhD in 2015. Her dissertation research focused on the impact of ELA and mast cells in the IL10-/- murine model of spontaneous colitis. She was awarded an NIH K01 Award, and is currently an assistant professor of Small Animal Internal Medicine at the UPenn, College of Veterinary Medicine, where she is investigating the role of mast cells in inflammatory bowel disease.

Yihang Li, PhD, Dr. Li joined the GISBL in 2015 where he conducted his post-doctoral research focused on the regulation of and mechanisms by which stress regulates intestinal epithelial nutrient transporter function and role in nutrient partitioning in immune and adipose tissue. In 2018, Yihang was recruited to the University of Delaware where he is an assistant professor of Physiology in the Department of Animal Science.

Julia Medland, MS– Julia received her MS degree in 2015 from the GISBL. Her MS thesis, entitled “Development of the Enteric Nervous System in a Porcine Model of Early Life Stress: Implications for Long-Term Intestinal Disease Susceptibility” focused on the impact of ELA on development of the enteric cholinergic nervous system expression and function. Julia is currently pursuing a DVM degree at NC State University, College of Veterinary Medicine.

Calvin Pohl, DVM PhD- Dr. Pohl earned his PhD from the GISBL in 2018. His dissertation research was focused on understanding the impact of psychological and infectious stressors on enteric cholinergic system development and function and its subsequent effects on GI barrier and immune function in murine and porcine models. Dr. Pohl is currently pursuing post-doctoral research training at Abbvie (Chicago, IL).

Mrigendra Rajput, BsVet, MS PhD- Dr. Rajput joined the GISBL in January 2015. Hi research in the GISBL focused on the influence of early life stress, associated with management practices in swine, on immune development and vaccine responsiveness. In 2018, Dr. Rajput accepted an Assistant Professor position Arkansas Tech University.