June 14, 2021 8:26 AM

Beginning Monday, June 14, 2021, the MSU Veterinary Medical Center will allow clients into the building with patients. Find details here.

Any patient presented to the MSU Small Animal Emergency Service will undergo an initial medical evaluation to determine if urgent care is needed, and whether hospitalization is warranted. The MSU Small Animal Emergency Service will only hospitalize patients that our clinicians consider to be unstable or to have life-threatening conditions.

This summer, the MSU College of Veterinary Medicine welcomed a new chair to the Department of Pathobiology and Diagnostic Investigation. Dr. Srinand Sreevatsan came to MSU from the University of Minnesota, where he was a professor of infectious disease at the Veterinary Population Medicine Department and director of Graduate Studies. His research focuses on the pathobiology and molecular evolution of several zoonotic pathogens, especially mycobacteria and influenza.

“I’ve dedicated my scientific career to zoonotic disease investigations at the cellular and molecular level. My focus has been on bovine tuberculosis and influenza.”
 — Dr. Srinand Sreevatsan

Sreevatsan joins the ranks of the College’s top-tier researchers that are focused on the One Health initiative; they work toward improving the health and safety of food products, livestock, humans, and the environment.

“Dr. Sreevatsan’s research, bridging basic understanding of microbial biology with detection and treatment methods, is especially valuable as we continue to learn about the consequences that antibiotics, farm management practices, waste disposal, and other factors can have on our world,” says Dr. Vilma Yuzbasiyan-Gurkan, associate dean for Research and Graduate Studies. “As we continue to innovate and produce novel diagnostics, therapies, and practices, we can effect change where our world most needs it.”

Bovine Tuberculosis

In developed countries, bovine tuberculosis (bTB) is detected and destroyed before food products make it into the human food chain; it is detected in beef cows at slaughter and pasteurization kills it in milk. But bTB passed to deer and other free-ranging mammals in nature can be passed back to domestic cow populations, putting humans who work with the livestock at risk; humans consuming infected food products also are at risk.
 
Sreevatsan’s research of bTB focuses on interspecies transmission, usually between wild and domestic animals and domestic animals and humans. His studies have focused on locations ranging from China, Thailand, Uganda, and Brazil, specifically in pastoral settings.

“We’ve developed tools to identify proteomic evidence of mycobacterial peptides, and we’re able to apply this data as we examine cattle and deer populations, which are the most concerning reservoirs for transmission events in the United States,” says Sreevatsan.

To address bTB in the States, Sreevatsan and his team are developing a nanoparticle-based sub-unit bacterial vaccine to immunize deer orally and stimulate local mucosal immunity.

“Our goal is to lessen the prevalence of tuberculosis in the wild, thereby affecting its transmission to domestic cattle populations,” says Sreevatsan.

Influenza

Sreevatsan is using genomic epidemiology and sequencing to look for influenza signatures in avian and swine populations. Using this methodology, he and his fellow researchers can identify which strains of influenza are currently circulating, allowing them to better anticipate whether or not any highly transmittable strains will surface during a particular season.

For his influenza work, Sreevatsan is focusing on places where swine and humans often come into close contact, such as state or county fair exhibits and live animal markets. In these close quarters, not only is transmission more likely, but the opportunities for a new strain to be created increase.

In one of his most recent papers, Sreevatsan and his colleagues use a complete genomic sequencing of influenza virus A in swine to reveal the emergence and persistence of diverse viral genotypes.

“Swine are one of the reservoir species for influenza A viruses (IAVs), and as such, they play a major role in transmission across species,” says Sreevatsan. “By using next-generation sequencing technologies in our study, we were able to demonstrate both the complex distribution and diversity of IAVs and the dynamic evolution within these farms. These data are key as we work to advance health interventions that will reduce the risk of transmission between swine and humans.”

One Health

Throughout all of his research, Sreevatsan maintains one common theme: the importance of One Health. This year, he co-published a paper titled “The science behind One Health: at the interface of humans, animals, and the environment.” The paper focused on the Second International Conference on One Medicine One Science, which brought together scientists, experts, and regulatory authorities from 34 countries to discuss human impacts of air quality; complexities of water quality, access, and conflicts; opportunities and uncertainties in precision medicine; and the role of science communication in health policy formulation.

“The challenges experienced at local and regional levels in regard to human, animal, and environmental health are similar worldwide,” says Sreevatsan. “This international gathering to address our similar conflicts offered new opportunities for broadly applicable investigation and policy development.”

Also in this Issue:

The Dean’s Perspective Read More
Learn Read More
Greener Pastures

College and farm partner to improve veterinary education and the dairy industry of tomorrow.

Read More
Investing in the Future

MSU Donors’ Impact on the Dairy Industry.

Read More
Food Systems Fellowship Program

12 years of adding value to the student experience.

Read More
Not Just Medicine

Clerkship Series Teaches Professional Skills To Food Animal Veterinary Students.

Read More
Who will keep food safe? Spartans Will.

This Spartan is One of a Kind.

Read More
Experts Revamp Food Protection and Defense Course Read More
Online Continuing Education Emerges from the MSU Online Food Safety Program Read More
Discover Read More
Quality Milk Alliance

Prioritizes Mastitis Preventatives and Training.

Read More
Researching New Therapies and Preventatives

to Mediate GI-Triggered Autoimmune Disease.

Read More
Reducing Early-Life Adversity for Pig, Human Health Read More
Slowing Down Antibiotics and Speeding Up Herd Recovery Read More
Wake Up: Treating Tuberculosis by Stopping Dormancy

Treating Tuberculosis by Stopping Dormancy.

Read More
Heal Read More
Healing the Herd

Hospital Focuses on Prevention for Welfare and Food Safety.

Read More
Scholarships Empower

2017 Alumnus to Succeed in Dairy Herd Health Medicine.

Read More
Protect Read More
Food Safety and Public Health

Veterinarians Are Integral to the Process.

Read More
Defining and Fighting Food Fraud Read More
College Welcomes New PDI Chair, One Health Ambassador Read More
New curriculum offers opportunity for food animal students Read More
Class of 2021 Profile Read More
Alumni News Read More
In Memoriam Read More
Why Scholarships? Why Now?

Students are the lifeblood of the College, which is working to ensure that MSU is the top choice for prospective veterinary students.

Read More
Homecoming 2017 Read More
Celebration of Generosity 2017 Read More