Geriatric onset laryngeal paralysis polyneuropathy

GOLPP is a common clinical condition affecting geriatric, large-breed dogs in which the laryngeal innervation degenerates over time.

Affected dogs exhibit respiratory stridor, exercise intolerance, dyspnea, throat clearing, and may even collapse. Treatment includes surgical correction to relieve breathing, and is generally very successful. The most common post-operative risk is aspiration pneumonia.

Studies at MSU have shown that esophageal function is also affected in these dogs. It is suspected that a similar neurodegenerative process causes both laryngeal and esophageal changes. As esophageal function deteriorates, risk of post-op aspiration pneumonia increases. Over time, affected dogs will invariably progress to show generalized neurologic deterioration, initially most notable in their hind limbs. Overall, it appears idiopathic laryngeal paralysis is in fact part of a progressive generalized neuropathy. Due to these findings, it was determined the disease might be better termed geriatric onset laryngeal paralysis polyneuropathy, or GOLPP.